Zhonghua nei ke za zhi
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Zhonghua nei ke za zhi · May 2017
Meta Analysis[Levofloxacin-based triple therapy versus bismuth-based quadruple therapy in the treatment of Helicobacter pylori as the rescue therapy: a meta analysis].
Objective: To evaluate the efficacy of levofloxacin-based triple therapy and bismuth-based quadruple therapy in the treatment of Helicobacter pylori (Hp) infection as rescue regimens. Methods: Related randomized controlled trials assessing the efficacy and safety of levofloxacin-based triple therapy eradicating Hp as salvage treatment were retrieved from Pubmed, Cochrane Library, SPRINGER, VIP database, WanFang database and CKNI database. The literature quality was evaluated by the improved Jadad criterion. ⋯ The adverse effects were significantly lesser(19.1% vs 29.5%, OR=0.47, 95%CI 0.26-0.82, P<0.05), whereas the compliance rate was significantly higher in levofloxacin group (96.0% vs 89.9%, OR=2.27, 95%CI 1.33-3.87, P<0.05). Conclusions: Comparing with bismuth-based quadruple therapy, levofloxacin-based triple therapy has higher eradication rate, compliance rate and lesser side effects, so we recommend it as a second-line rescue therapy after front-line Hp eradication failure. The optimal second-line alternative scheme might differ among countries depending on quinolone resistance.
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Zhonghua nei ke za zhi · May 2015
Meta Analysis[A meta-analysis of probiotics for the treatment of irritable bowel syndrome].
To evaluate the efficacy of probiotics to treat irritable bowel syndrome (IBS). ⋯ Probiotics have beneficial effects on IBS, which can improve the patients' symptoms and with less adverse reaction. Due to the bias, further large-scale, multicenter and high-quality RCTs are required to unify outcome indicators, further define sensitive strain, and standardize its usage, dosage and course of treatment.
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Zhonghua nei ke za zhi · Jan 2014
Meta Analysis[Effects of sucralfate and acid-suppressive drugs on preventing ventilator- associated pneumonia of mechanically ventilated patients: a meta-analysis].
To evaluate the effect of sucralfate and acid-suppressive drugs on preventing ventilator-associated pneumonia (VAP) in mechanically ventilated patients. ⋯ In patients with mechanical ventilation, sucralfate could decrease the incidence of VAP, while has no such effect on the stress-related gastrointestinal bleeding, the days on ventilator, duration of ICU stay and ICU mortality.
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Zhonghua nei ke za zhi · Oct 2012
Meta Analysis Comparative Study[The effects and safety of closed versus open tracheal suction system: a meta analysis].
To evaluate the effects and safety of closed tracheal suction system(CTSS) versus open tracheal suction system (OTSS) for mechanically ventilated patients. ⋯ Compared with OTSS, CTSS could reduce disturbance to respiratory and circulatory system by sputum suction and shorten the duration of mechanical ventilation. However, CTSS has no advantage in prevention of ventilator associated pneumonia or microbial colonization, nor does it shorten the length of ICU stay or improve the outcome of mechanically ventilated patients.
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Zhonghua nei ke za zhi · Apr 2011
Meta Analysis[A meta-analysis of the effects of direct hemoperfusion with polymyxin B-immobilized fiber on prognosis in severe sepsis].
To investigate the effects of direct hemoperfusion with polymixin B-immobilized fiber (DHP-PMX) in patients with sepsis. ⋯ This study suggests a favorable effects of DHP-PMX on mortality and endotoxin decreasing in patients with sepsis. However, lack of enough cases and blinding need to be considered. Further investigation with large sample of high quality RCTs is needed.