Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
-
Comparative Study
Comparison of thermal threshold tests to assess small nerve fiber function: limits vs. levels.
The method of limits (MLI) and the method of levels (MLE) are psychophysical stimulus procedures most commonly applied to quantify warm and cold sensation thresholds in humans. This paper evaluates basic methodological properties of both methods and investigates the correspondence between the method's results. ⋯ Statistical testing shows that model-based MLI threshold equals MLE threshold provided MLE TRAP stimuli are used. Recommendations for optimal MLI and MLE stimulus configurations and properties are given in relation to application of quantitative sensory testing.