Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
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To investigate the relationships between brain function and some of the most frequently impaired cognitive domains in the first stages of Alzheimer's disease (AD), we searched for correlation between the scores on 3 neuropsychological tests and brain perfusion, assessed by single photon emission computed tomography (SPECT) in patients with very mild AD. ⋯ Assessing the relationships between neuropsychology and brain functional imaging is a key approach to clarify the pathophysiology of cognitive failure in AD; the specificity of these findings in AD remains to be proven through comparison with correlation achieved in matched controls.
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This study aims to identify the symptoms, signs and distributions which are associated with neurophysiological carpal tunnel syndrome (N-CTS), defined by the finding of a median nerve lesion at the wrist through neurophysiologic studies, and to compare them with those of patients with sensory or motor complaints in the upper limbs whose electrophysiologic investigation did not show evidence of this syndrome. ⋯ One concludes that the most characteristic manifestation of carpal tunnel syndrome (CTS) is paresthesia. Pain also occurs very frequently but it is less specific, and weakness, meanwhile, seems to have a low frequency. We believe that the variability in the clinical presentation of CTS is largely due to the presence of associated diseases and our results provide information which could help to better define the clinical criteria used in the diagnosis of this syndrome.
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To investigate the effects of mexiletine, an analog of lidocaine, on excitability of human axons in vivo. ⋯ Measurements of the excitability indices can be used for non-invasive assessment and monitoring of the effects of mexiletine in patients with neuropathic pain or muscle cramps.