Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
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To study interobserver variation in the interpretation of median nerve SSEPs in patients with anoxic-ischaemic coma. ⋯ Because of its moderate interobserver agreement, great care has to be given to accurate recording and interpretation of SSEPs before using the recordings for non-treatment decisions.
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Previous axonal excitability studies in amyotrophic lateral sclerosis (ALS) have suggested that impaired potassium channel function could be responsible for the generation of fasciculations, but the ectopic activity arises predominantly from the motor nerve terminals. This study tested the hypothesis that dysfunction of potassium channels is more pronounced in the more distal parts of axons. ⋯ Excitability testing at the motor point provides additional information about the pathophysiology of ALS.
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Randomized Controlled Trial Comparative Study Clinical Trial
Transcranial magnetic stimulation for pain control. Double-blind study of different frequencies against placebo, and correlation with motor cortex stimulation efficacy.
To assess, using a double-blind procedure, the pain-relieving effects of rTMS against placebo, and their predictive value regarding the efficacy of implanted motor cortex stimulation (MCS). ⋯ Defining rTMS parameters is a crucial step before proposing rTMS as predictive test of SCM efficacy in clinical practice.
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Comparative Study
Sympathetic facilitation of hyperalgesia evoked from myofascial tender and trigger points in patients with unilateral shoulder pain.
To provide evidence for the sympathetic-sensory interaction within a trigger point, which may contribute to local and referred pain and sympathetic symptoms in myofascial pain syndrome. ⋯ Sympathetic hyperactivity needs to be considered during the clinical evaluation and management of myofascial pain syndrome.
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Historical Article
Axonal excitability properties in amyotrophic lateral sclerosis.
To investigate axolemmal ion channel function in patients diagnosed with sporadic amyotrophic lateral sclerosis (ALS). ⋯ An increase in persistent Na+ conductances coupled with reduction in K+ currents would predispose axons of ALS patients to generation of fasciculations and cramps. Axonal excitability studies may provide insight into mechanisms responsible for motor neuron loss in ALS.