Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
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Comparative Study Clinical Trial
A look inside the nerve - Morphology of nerve fascicles in healthy controls and patients with polyneuropathy.
Polyneuropathies are increasingly analyzed by ultrasound. Summarizing, diffuse enlargement is typical in Charcot-Marie Tooth type 1 (CMT1a), regional enlargement occurs in inflammatory neuropathies. However, a distinction of subtypes is still challenging. Therefore, this study focused on fascicle size and pattern in controls and distinct neuropathies. ⋯ Pattern analysis of fascicles might facilitate distinction of several otherwise similar neuropathies.
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Healthy subjects can learn to use cognitive-emotional strategies to suppress their spinal nociception, quantified by the nociceptive flexor reflex (RIII reflex), when given visual RIII feedback. This likely reflects learned activation of descending pain inhibition. Here, we investigated if training success persists 4 and 8 months after the end of RIII feedback training, and if transfer (RIII suppression without feedback) is possible. ⋯ These results are an important pre-requisite for application of RIII feedback training in the context of clinical pain.