Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
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Transcranial direct current stimulation (tDCS) is a neuromodulation scheme that delivers a small current via electrodes placed on the scalp. The target is generally assumed to be under the electrode, but deep brain regions could also be involved due to the large current spread between the electrodes. This study aims to computationally evaluate if group-level hotspots exist in deep brain regions for different electrode montages. ⋯ The presented EF atlas in deep brain regions can be used to explain tDCS mechanism or select the most appropriate tDCS montage.
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Patients with Parkinson's disease (PD) have deficits in lower-limb functions such as gait, which involves both cognitive and motor dysfunction. In PD, theta and beta brain rhythms are associated with cognitive and motor functions, respectively. We tested the hypothesis that PD patients with lower-limb abnormalities would exhibit abnormal theta and beta rhythms in the mid-frontal cortical region during lower-limb action. ⋯ These data provide insight into mechanisms of lower-limb dysfunction in PD with FOG.