The American journal of otology
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Comparative Study
Ototoxicity resulting from combined administration of metronidazole and gentamicin.
The hypothesis that metronidazole can augment the ototoxicity of gentamicin was tested. ⋯ These data support the clinical observation of augmented ototoxicity in patients receiving combined gentamicin and metronidazole. Caution should be used when administering these two agents together. Clinicians should consider other antibiotic strategies whenever possible.