Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
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Zhonghua Gan Zang Bing Za Zhi · Feb 2020
[Novel coronavirus pneumonia-related liver injury: etiological analysis and treatment strategy].
The outbreak of pneumonia caused by 2019 novel coronavirus infection in Wuhan has become a public health emergency of international concern. However, some patients are accompanied by varying degrees of liver injury in addition to respiratory symptoms. This paper analyzes the clinical characteristics, susceptible population, related factors and treatment strategies to provide a reference for clinical decision making in novel coronavirus pneumonia-related liver injury.
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Zhonghua Gan Zang Bing Za Zhi · Feb 2020
[Exploring the mechanism of liver enzyme abnormalities in patients with novel coronavirus-infected pneumonia].
Objective: To explore and analyze the possible mechanism of liver injury in patients with coronavirus disease 2019 (novel coronavirus pneumonia, NCP). Methods: The correlation between ALT, AST and other liver enzyme changes condition and NCP patients' disease status reported in the literature was comprehensively analyzed. ACE2 expression in liver tissue for novel coronavirus was analyzed based on single cell sequencing (GSE115469) data. ⋯ Whether this phenomenon suggests that the bile duct epithelial cells with positive expression of Ace2 participate in the process of liver regeneration after partial hepatectomy deserves further study. In RNA-Seq data, 77 transcription factors were positively correlated with the expression of Ace2 (r > 0.2, FDR < 0.05), which were mainly enriched in the development, differentiation, morphogenesis and cell proliferation of glandular epithelial cells. Conclusion: We assumed that in addition to the over activated inflammatory response in patients with NCP, the up-regulation of ACE2 expression in liver tissue caused by compensatory proliferation of hepatocytes derived from bile duct epithelial cells may also be the possible mechanism of liver tissue injury caused by 2019 novel coronavirus infection.