Electromyography and clinical neurophysiology
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Electromyogr Clin Neurophysiol · Apr 2003
Increased creatine kinase and spontaneous activity on electromyography, in amyotrophic lateral sclerosis.
Mild to moderate elevation of muscle creatine kinase (CK) is commonly observed in amyotrophic lateral sclerosis (ALS). Although the determinants of increased the CK in ALS remain uncertain, we hypothesize that fasciculations and muscle denervation can be involved by damaging the muscle fibre. ⋯ The fasciculations,and the signs of denervation on EMG, are not determinants for high CK values in ALS patients, which are still unknown. Increased CK can be useful in the differential diagnosis of patients with lower motor neuron disorders.