Diabetes/metabolism research and reviews
The most recent articles from:
May 2018
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Diabetes Metab. Res. Rev. · May 2018
Sepsis-induced activation of endogenous GLP-1 system is enhanced in type 2 diabetes.
High levels of circulating GLP-1 are associated with severity of sepsis in critically ill nondiabetic patients. Whether patients with type 2 diabetes (T2D) display different activation of the endogenous GLP-1 system during sepsis and whether it is affected by diabetes-related metabolic parameters are not known. ⋯ Taken together, these data indicate that endogenous GLP-1 system is activated during sepsis. Patients with T2D display an enhanced and prolonged activation as compared to nondiabetic patients. Extreme early increased GLP-1 levels during sepsis indicate poor prognosis.