Rheumatology
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Comparative Study
Central neural mechanisms of interindividual difference in discomfort during sensorimotor incongruence in healthy volunteers: an experimental study.
It has been reported that disturbance in sensory and motor function may induce sensorimotor incongruence and produce pain, discomfort and other sensations in healthy volunteers. One study suggested that sensorimotor incongruent information to healthy subjects results in increased neuronal activity in the posterior parietal cortex (PPC) and dorsolateral prefrontal cortex; however, this study did not take into consideration the discomfort induced by sensorimotor incongruence. The present study attempted to characterize intracortical electrical activities for sensorimotor incongruence in the frequency domain. In our study, electroencephalogram (EEG) cortical sources were compared between sensorimotor congruence and sensorimotor incongruence. In addition, high and no discomfort subgroups were compared during sensorimotor incongruence. ⋯ The present findings suggest that the ACC and PCC are more activated in the high-discomfort subgroup than in the no-discomfort subgroup during sensorimotor incongruence. This method may evaluate the effectiveness of new medication therapy and/or rehabilitation by assessing the difference in the neuronal activity of chronic patients before and after treatment.
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The aim of this study was to determine demographic, clinical, articular and laboratory variables predicting etanercept response in JIA. ⋯ Parameters predicting a high-grade response to a 6-month course of etanercept were identifiable and included age at treatment start, disease duration before treatment, JIA category other than systemic arthritis, CHAQ, parents' global assessment and concomitant corticosteroids.
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Complex regional pain syndrome (CRPS) describes a broad spectrum of symptoms that predominantly localize to the extremities. Although limb fracture is one of the most frequently reported triggering events, few large-scale studies have shown the occurrence of and factors associated with CRPS following limb fracture. This study aimed to show the occurrence and identify of those factors. ⋯ Although a limited number of CRPS patients were analysed in this study, reduced operative time might help to prevent the development of acute CRPS following limb fracture.