Cardiovascular research
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Cardiovascular research · Oct 2004
Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat.
This study sought to characterize changes in the angiopoietin system in a rat model of myocardial infarction (MI). ⋯ Thus, myocardial ischemia induced by left coronary artery ligation resulted in a sustained increase in Ang-2 expression and a reciprocal decrease in Ang-1, consistent with a predominant role for Ang-2 in the angiogenic response to MI.