Cardiovascular research
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Cardiovascular research · Mar 2005
Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes.
To examine if adenosine prevents oxidant-induced mitochondrial dysfunction by producing nitric oxide (NO) in cardiomyocytes. ⋯ Adenosine protects mitochondria from oxidant damage through a pathway involving A(2) receptors, eNOS, NO, PI3-kinase/Akt, and Src tyrosine kinase.