Cardiovascular research
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Cardiovascular research · Jul 2015
Combination therapy with remote ischaemic conditioning and insulin or exenatide enhances infarct size limitation in pigs.
Remote ischaemic conditioning (RIC) has been shown to reduce myocardial infarct size in patients. Our objective was to investigate whether the combination of RIC with either exenatide or glucose-insulin-potassium (GIK) is more effective than RIC alone. ⋯ GIK and exenatide activate cardioprotective pathways different from those of RIC, and have additive effects with RIC on infarct size reduction in pigs.