Dementia (London, England)
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In 2011, the U. S. National Institute on Aging published guidelines for clinical diagnostics for Alzheimer's disease dementia. ⋯ No studies exist showing the progression of these biomarkers to Alzheimer's disease. There is also a lack of empirical evidence showing how biomarkers determine mild cognitive impairment, which has multiple etiologies. The guidelines fail to explain anomalies where there are biomarkers but no expression of Alzheimer's disease.