Journal of managed care & specialty pharmacy
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J Manag Care Spec Pharm · Aug 2014
Observational StudyAdherence to multiple medications prescribed for a chronic disease: a methodological investigation.
Many patients receive multiple medications for the treatment of a disease. While monitoring adherence is important, a composite measure of adherence is useful for estimating adherence to multiple medications in these patients. There are multiple ways to compute composite estimates of adherence to multiple medications, including (a) 80% of days covered by at least 1 medication ("at least 1"); (b) 80% of days covered by both medications ("both"); (c) 80% of days covered by each medication measured separately ("all"); and (d) computing an average of the individual medication adherence estimates ("average"). Comparison of adherence rates to individual medications and that of composite estimates are important for intervention decisions and effective disease management. ⋯ Subjects were found to have a level of adherence-as estimated by individual medication adherence and composite adherence metrics-for multiple medications prescribed for a disease that, while not optimal from the perspective of patient care, was not entirely poor. In addition, composite estimates of adherence considerably varied depending on algorithms used. Most importantly, a large number of patients appeared to be subject to inconsistent classification based on adherence measurement algorithm. Adherence estimates produced by different composite measurement approaches give rise to difficulty in consistent interpretation, which may be detrimental to appropriate patient care decision making.
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J Manag Care Spec Pharm · Aug 2014
Association between dispensing channel and medication adherence among medicare beneficiaries taking medications to treat diabetes, high blood pressure, or high blood cholesterol.
Medication adherence, defined as taking medications as prescribed, is a key component in controlling disease progression and managing chronic illnesses such as diabetes, hypertension, and high blood cholesterol. These diseases constitute 3 of the top 5 most prevalent conditions among Medicare beneficiaries, warranting further attention to find ways to promote better medication adherence. The scientific literature has established the clinical and financial benefits of medication adherence and the role of dispensing channel in impacting adherence to medications. However, a common limitation in channel-adherence studies is the failure to control for healthy adherer effect (HAE), referring to individuals who are likely to engage proactively in activities that improve their adherence. Healthier individuals may choose the home-delivery channel to ensure continuity in their medication regimens and to minimize obstacles to adherence, such as inadequate access, inconvenience, and financial concerns. Thus, better medication adherence in home delivery may reflect healthier patients' predisposition to self-select for home delivery options. To accurately attribute the impact of dispensing channel on adherence, research would need to control for bias from a patient's predisposition to be adherent. ⋯ After excluding patients who received any prescriptions via home delivery auto refill programs and controlling for PAB, differences in days supply, low-income subsidy status, demographics, and disease burden, Medicare beneficiaries who use home delivery for antidiabetics, antihypertensives, or antihyperlipidemics have a greater likelihood of being adherent than patients who fill their prescriptions at retail. The results of this study provide evidence that where medications are received may impact adherence, even when controlling for PAB. Use of the home delivery dispensing channel may be an effective method to improve adherence for Medicare beneficiaries.
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J Manag Care Spec Pharm · Aug 2014
Adherence and persistence to prescribed medication therapy among Medicare part D beneficiaries on dialysis: comparisons of benefit type and benefit phase.
The implementation of Medicare Part D provided insurance coverage for outpatient medications, but when persons reach the "gap," they have very limited or no medication insurance coverage until they reach a second threshold for catastrophic coverage. In addition, some patients have a low-income subsidy (LIS), and their out-of-pocket costs do not reach the threshold for the gap. Little is known about how these Part D types (LIS versus non-LIS) and benefit phases (before the gap, during the gap, after the gap) affect medication adherence and persistence of dialysis patients. ⋯ More than half of Medicare beneficiaries on dialysis reached the Part D coverage gap in 2007. Our findings suggest that the Part D coverage gap was significantly associated with decreases in adherence and persistence for medications frequently used in patients undergoing dialysis. Patients who reached the coverage gap (Cohort 2) often decreased use of or discontinued critical medications after reaching the coverage gap. Compared with patients who had an LIS (Cohort 4), patients in Cohort 2 had significantly lower medication adherence and persistence levels. The negative impact of the Part D coverage gap (high out-of-pocket cost sharing) on medication adherence and persistence for Medicare-eligible dialysis patients has implications for currently proposed Medicare end-stage renal disease bundled reimbursement payment and requires more research.
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J Manag Care Spec Pharm · Aug 2014
Observational StudyConcurrent use of comedications reduces adherence to antiretroviral therapy among HIV-infected patients.
The use of highly active antiretroviral therapy has significantly reduced morbidity and mortality, thus increasing life expectancy of human immunodeficiency virus (HIV)-infected individuals, transforming HIV into a chronic disease. Accordingly, there has been an increase in the number of comorbidities concomitantly present in these individuals and also an increased use of comedications, which may negatively impact antiretroviral therapy adherence. These factors can affect adherence to antiretroviral therapy. The role of the HIV clinical pharmacist is essential to achieve therapeutic objectives and enhance adherence. ⋯ Recently, the number of HIV-infected patients with polypharmacy has been higher, increasing the risk of nonadherence. Furthermore, previous treatment with antiretroviral therapy, HIV transmission by intravenous drug use, and high risk of drug-related problems are also associated with lower adherence.