Journal of the Egyptian National Cancer Institute
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J Egypt Natl Canc Inst · Sep 2006
Ipsilateral in-breast tumor relapse after breast conservation therapy: true recurrence versus new primary tumor.
Ipsilateral breast tumor relapse (IBTR) occurs in approximately 8-20% of women 10 years after breast conservation therapy (BCT). The aim of this study is to classify ipsilateral breast tumor relapses in patients treated with conservative surgery and radiation therapy as true recurrences or new primary and to show the clinical significance of classification into these two types of recurrences. ⋯ It appears that a significant portion of patients who experience ipsilateral breast tumor relapse following conservative surgery and radiation therapy have new primary tumors as opposed to true recurrences. Patients with a new primary had better survival rates than those with true recurrence. Distinguishing new primary breast carcinoma from local disease recurrence may have importance in therapeutic decisions and chemoprevention strategies.
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J Egypt Natl Canc Inst · Sep 2006
Randomized Controlled TrialLocally advanced rectal carcinoma: preoperative radiotherapy versus postoperative chemoradiation, 10-year follow-up results of a randomized clinical study.
A prospective study was designed to randomize locally advanced rectal carcinoma patients between either preoperative radiotherapy (+/- postoperative chemotherapy) or postoperative adjuvant chemoradiation. Two end points were evaluated, local recurrence and survival, aiming at defining prognostic parameters that can help in the choice of the optimum treatment modality. ⋯ This work showed equal results for DFS and OS rates between preoperative and postoperative radiation therapy with the same acceptable acute and late radiation toxicity. High dose preoperative irradiation did not cause any significant increase in acute or late radiation induced reactions, delay in wound healing or increased postoperative morbidity when compared to postoperative adjuvant radiochemotherapy. Duke' s stage and response to preoperative irradiation proved to be of significance regarding DFS, while compliance to systemic therapy was of significance regarding both OS and DFS.