Evidence-based dentistry
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Evidence-based dentistry · Jun 2018
Meta AnalysisNon-pharmacological pain relief during orthodontic treatment.
Data sourcesA comprehensive literature search in all languages was carried out. Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (till 6 October 2016), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, 2016, Issue 9), MEDLINE Ovid (1946 till October 6th, 2016), Embase Ovid (1980 till October 6th, 2016) and EThOS (till October 6th, 2016). ⋯ Authors were contacted to clarify study information. Study selectionThe inclusion criteria of studies were defined as patients undergoing orthodontic treatment, up to 18 years of age.
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Data sourcesMedline via PubMed, the Web of Science and the Cochrane Library were searched until April 2014. Study selectionRandomised controlled trials (RCTs) comparing the efficacy of botulinum toxin type A (BoTN-A) with placebo in patients with painful trigeminal (TN) and postherpetic neuralgia (PHN) reporting changes in pain intensity in patients aged 19 years and older available in English were included. Data extraction and synthesisThree authors independently assessed for inclusion, extracted standard data and assessed for risk of bias. ⋯ Standardised difference in mean post treatment pain (six studies) was -0.918 (95% CI -1.197 to -0.639 p<0.001) in favor of BoTN-A. For the percentage of patients experiencing 50% pain reduction (three studies) absolute risk difference and relative risk were calculated (RR 2.892, 95% CI 1.726 to 4.848 p<0.001) in favour of the use of BoTN-A. ConclusionsThe authors concluded that there is moderate evidence regarding the efficacy of BoTN-A in treating patients with trigeminal neuralgia and postherpetic neuralgia.