Open forum infectious diseases
-
Open Forum Infect Dis · Nov 2018
Unusually High Incidences of Pseudomonas Bacteremias Within Topical Polymyxin-Based Decolonization Studies of Mechanically Ventilated Patients: Benchmarking the Literature.
Topical polymyxin (PM)-based regimens to decolonize patients receiving prolonged mechanical ventilation (MV) have been widely studied. However, paradoxical bacteremia incidences remain unexplained. ⋯ Paradoxically, despite an apparent prevention effect of topical PM-based methods against bacteremia overall, the incidences of Pseudomonas bacteremia within the component groups of these studies are unusually high vs literature-derived benchmarks.