Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
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This meta-analysis aims to determine the effect of folic acid supplementation on colorectal cancer risk. ⋯ At the 3-year colonoscopic follow up, folate supplementation had no effect on adenoma recurrence overall. While colonic surveillance beyond 3 years revealed an increased risk of colorectal adenoma, especially advanced adenoma, among those participants randomized to the folate group. This meta-analysis challenges the results from epidemiological studies that folate status is inversely related to the risk of developing colorectal cancer.
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Sacral nerve stimulation (SNS) is an effective but expensive treatment for faecal incontinence. About 50% of the patients are unresponsive for unknown reasons, hence knowledge of any factors predictive of success would be highly desirable. The aim of this study was to analyse the potential factors associated with a successful outcome of the temporary test of electrostimulation. ⋯ Use of the quadripolar electrode is the only factor significantly related to the success of SNS.