Klinische Wochenschrift
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Klinische Wochenschrift · Feb 1979
[Digoxin induced changes in the exercise ECG and its relation to plasma concentrations (author's transl)].
The effects of a single intravenous dose (1.5 mg) of diogoxin on the resting and exercise ECG were studied over several days in twelve normal subjects. Maximal ST-segment and T-wave changes were observed 24 h after drug administration. ⋯ There was no correlation between digoxin plasma concentration and ECG-changes. In order to avoid false positive ischaemic ST-segment responses to exercise, a therapy with digoxin should be discontinued for at least 2 weeks before the exercise test.