Pediatric research
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Comparative Study
Feasibility and short-term effects of biphasic positive airway pressure versus assist-control ventilation in preterm lambs.
Biphasic positive airway pressure (BiLevel) ventilation allows utilization of two alternating positive end-expiratory pressures (PEEP) while permitting unrestricted spontaneous breathing with superimposed synchronized pressure support. We aimed to compare whether BiLevel versus assist-control (A-C) ventilation provides effective gas exchange and reduces severity of early lung injury in preterm lambs. Preterm lambs delivered at 134 d (term = 150 d) were quasirandomized to BiLevel (PEEP low/high 5/20 cm H2O) or A-C5 (PEEP 5 cm H2O) ventilation. ⋯ There were no significant differences between groups in baseline characteristics, oxygenation index (p = 0.49), or partial pressure of carbon dioxide (Paco2) (p = 0.08). BiLevel group lambs showed improved pressure-volume relationship (p = 0.006), lower lung inflammatory score (p = 0.013), and trend toward lower messenger RNA expression of markers of lung injury compared with A-C5 group lambs. In unsedated preterm lambs, BiLevel ventilation provides gas exchange equivalent to A-C ventilation and potentially results in reduced lung injury.
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To determine the effects of bladderbox alarms during venoarterial extracorporeal membrane oxygenation (va-ECMO) on cerebral oxygenation and hemodynamics, six lambs were prospectively treated with va-ECMO and bladderbox alarms were simulated. Changes in concentrations of oxyhemoglobin (deltacO2Hb), deoxyhemoglobin (deltacHHb), and total Hb (deltactHb) were measured using near infrared spectrophotometry. Fluctuations in Hb oxygenation index (deltaHbD) and cerebral blood volume (deltaCBV) were calculated. ⋯ MAP, Qcar, and CVP recovered to preexperiment values but increased further with volume administration. HR was increased at the end of our measurements. We conclude that Bladderbox alarms during va-ECMO treatment result in significant fluctuations in cerebral oxygenation and hemodynamics, a possible risk factor for intracranial lesions.