Transplant infectious disease : an official journal of the Transplantation Society
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Review Comparative Study
Amphotericin B and its new formulations: pharmacologic characteristics, clinical efficacy, and tolerability.
Amphotericin B (amB) remains the gold standard for the treatment of invasive fungal infections. However, the efficacy is limited, with response rates from 10% to 80%. Moreover, amB is toxic, especially for the kidneys. ⋯ In sum, the new lipid formulations of amB are effective in various invasive fungal infections. The three formulations exhibit reduced nephrotoxicity compared with conventional amB. Large-scale comparative clinical trials may clarify issues of relative efficacy in various forms of mycotic infections.