Transplant infectious disease : an official journal of the Transplantation Society

The most recent articles from: Transpl Infect Dis April 2011

Transpl Infect Dis · Apr 2011

Monthly screening for BK viremia is an effective strategy to prevent BK virus nephropathy in renal transplant recipients.

BK polyomavirus virus (BKV) nephropathy (BKVN) is the most common viral infection that affects renal allografts. Because a specific antiviral therapy is lacking, BKVN may result in graft dysfunction and/or loss. We prospectively analyzed whether monthly nucleic acid testing (NAT) for BKV replication in blood and immediate reduction of immunosuppression (IS) could prevent BKVN. ⋯ BKV infection is an early complication. Monthly NAT in blood during the first 6 months and immediate reduction of IS in viremic patients almost completely prevent definitive BKVN.

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