Oftalmologia (Bucharest, Romania : 1990)
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Comparative Study Clinical Trial
[Potentiated loco-regional anesthesia in ophthalmological surgery].
A clinical study on 46 patients, who were operated on for ophthalmologic diseases under local anaesthesia, is presented. Midazolam, diazepam and/or pethidine, given to the patients 5-10 minutes before the operation improved the classical local anaesthesia; they ensured hypnosis, analgesia, anterograde amnesia and vegetative protection, thus offering a high surgical comfort and diminishing considerably the rate of the well known incidences and complications of the local anaesthesia.
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The study represent an up-to-date of the role and place of alpha 2-adrenergic agonists in glaucoma treatment. The first available alpha 2-agonist, clonidine is of historical importance today. Apraclonidine decrease the aqueous humor secretion and episcleral venous pressure. ⋯ Brimonidine has hypotensor effect similar with timolol but with a greater incidence of adverse local reactions. It has been no effects on cardiopulmonary function. Brimonidine would be of value as first-line therapy in patients who have contraindications to beta-blockers.
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Considered rare and occurring only in immunocompromised patients or patients with severe infection, Toxoplasma gondii chorioretinitis--as a unique presenting sign of toxoplasmosis appears to occur with increased frequency over the last few years in immunocompetent patients. The typical clinical picture (central chorioretinal lesion with recurrent vasculitic reactions) and positive IgG Toxoplasma gondii serology confirmed our diagnosis. Negative Toxoplasma IgG serology in the mothers of 2 patients excluded the possibility of congenital toxoplasmosis. Clinicians should be aware of the possibility of increased frequency of ocular toxoplasmosis in immunocompetent patients.