Sudebno-meditsinskaia ekspertiza
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The article deals with analysis of toxicokinetics of organophosphorous compounds (malathion and trichlorfon) in blood and of its changes in critical situations (shock, coma). In these forms of viability disturbances provided for mass-transfer and accumulation of poisonous substances in gastrointestinal tract their kinetics was shown to decelerate substantially. Active detoxification therapy improves markedly the parameters of organophosphorous insecticide kinetics. The parameters of toxicokinetics were recommended for use as objective criteria in estimation of intoxication gravity and therapy efficacy.
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Three programs for computer microcalculators "Elektronika MK-52", "Elektronika MK-54", "Elektronika MK-56", "Elektronika MK-61", and "Elektronika BZ-34" were studied. The first program allows one to calculate degree of substance extraction and rate of its distribution between two liquid unmixing phases; the second program is used for calculations on substance distribution in the organs of laboratory animals; the third program helps to calculate specific and molar rates of light absorption. Programs may be used in mathematical processing of results obtained in scientific research.