Journal of clinical neuromuscular disease
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J Clin Neuromuscul Dis · Dec 2012
Case ReportsLower extremity predominant stiff-person syndrome and limbic encephalitis with amphiphysin antibodies in breast cancer.
A 54-year-old woman presented with several weeks of psychiatric symptoms, partial-onset seizures, and painful spasms of the lower extremities. On examination, she exhibited severe stiffness and intermittent extensor spasms of the lower extremities. ⋯ Radiographic screening for malignancy disclosed a metastatic breast cancer. The case is a unique example of amphiphysin autoimmunity, illustrating the possibility of paraneoplastic stiff-person syndrome and limbic encephalitis coexisting in a patient with a "classical" presentation of stiff-person syndrome confined to the lower extremities.