Neuro-oncology
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Expression of programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) across glioma grades is undocumented, and their interactions with commonly expressed genetic and epigenetic alterations are undefined but nonetheless highly relevant to combinatorial treatments. ⋯ Targeting immune checkpoints in combination with other therapeutics based on positive biomarker selection will require screening of large patient cohorts.