European journal of heart failure
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Eur. J. Heart Fail. · Dec 2008
Randomized Controlled Trial Multicenter Study Clinical TrialOral levosimendan in patients with severe chronic heart failure --the PERSIST study.
Intravenous levosimendan improves symptoms in acutely decompensated heart failure. ⋯ Levosimendan improved QoL and decreased NT-proBNP but did not improve the Patient Journey composite in patients with severe CHF. Further research with this compound is warranted to clarify safety and efficacy.