European journal of heart failure
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Eur. J. Heart Fail. · Jul 2014
Randomized Controlled TrialSpinal cord stimulation is safe and feasible in patients with advanced heart failure: early clinical experience.
Pre-clinical work suggests that upper thoracic spinal cord stimulation (SCS) may have therapeutic effects in the treatment of heart failure (HF). We therefore aim to assess the safety and feasibility of SCS in HF patients. ⋯ This study shows that an SCS system can be safely implanted in patients with advanced HF and that the SCS system does not interfere with ICD function.
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Eur. J. Heart Fail. · Jul 2014
Baseline characteristics and treatment of patients in prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF).
To describe the baseline characteristics and treatment of the patients randomized in the PARADIGM-HF (Prospective comparison of ARNi with ACEi to Determine Impact on Global Mortality and morbidity in Heart Failure) trial, testing the hypothesis that the strategy of simultaneously blocking the renin-angiotensin-aldosterone system and augmenting natriuretic peptides with LCZ696 200 mg b.i.d. is superior to enalapril 10 mg b.i.d. in reducing mortality and morbidity in patients with heart failure and reduced ejection fraction. ⋯ PARADIGM-HF will determine whether LCZ696 is more beneficial than enalapril when added to other disease-modifying therapies and if further augmentation of endogenous natriuretic peptides will reduce morbidity and mortality in heart failure and reduced ejection fraction.
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Eur. J. Heart Fail. · Jul 2014
Prevalence of unrecognized heart failure in older persons with shortness of breath on exertion.
The majority of patients with heart failure are diagnosed in primary care, but underdiagnosis is common. Shortness of breath is a prevalent complaint of older persons and one of the key symptoms of heart failure. We assessed the prevalence of unrecognized heart failure in elderly patients presenting to primary care with shortness of breath on exertion. ⋯ Elderly primary care patients with shortness of breath on exertion often have unrecognized heart failure, mainly with preserved ejection fraction.
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Eur. J. Heart Fail. · Jul 2014
Review Meta AnalysisEffects of exercise training on depression in patients with heart failure: a systematic review and meta-analysis of randomized controlled trials.
The aim of this review is to assess the effects of exercise training on the symptoms of depression in heart failure (HF) patients. ⋯ Exercise training significantly decreased the symptoms of depression in patients with HF. This benefit remained unclear in cases of HF with a normal EF and combined aerobic and strength training. Random controlled trials are needed to verify the benefit of exercise in these populations, and in very old, asymptomatic, and severe HF patients.