European journal of heart failure
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Eur. J. Heart Fail. · Sep 2018
ReviewIncremental benefit of drug therapies for chronic heart failure with reduced ejection fraction: a network meta-analysis.
A network meta-analysis (NMA) of all recommended drug groups for the treatment of heart failure with reduced ejection fraction (HFrEF), including their combinations, was performed to assess the relative efficacy and incremental benefit. ⋯ Our analysis shows that the incremental use of combinations of disease-modifying therapies has resulted in the progressive improvement in mortality and hospitalization outcomes in HFrEF. Our findings support the current guideline recommendations.