European journal of heart failure
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Eur. J. Heart Fail. · Jul 2016
Review Meta AnalysisSystematic review and meta-analysis of iron therapy in anaemic adults without chronic kidney disease: updated and abridged Cochrane review.
Anaemia is increasingly recognized as having an independent impact upon patient outcomes in cardiac disease. The role of novel iron therapies to treat anaemia is increasing. This systematic review and meta-analysis assesses the efficacy and safety of iron therapies for the treatment of adults with anaemia. ⋯ Both oral and parenteral iron are shown to decrease the proportion of people who require blood transfusion and increase haemoglobin levels, without any benefit on mortality. Further trials at a low risk of bias, powered to measure clinically significant endpoints, are still required.
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Eur. J. Heart Fail. · Dec 2015
Meta AnalysisWhich heart failure patients profit from natriuretic peptide guided therapy? A meta-analysis from individual patient data of randomized trials.
Previous analyses suggest that heart failure (HF) therapy guided by (N-terminal pro-)brain natriuretic peptide (NT-proBNP) might be dependent on left ventricular ejection fraction, age and co-morbidities, but the reasons remain unclear. ⋯ The benefits of therapy guided by (NT-pro)BNP were present in HFrEF only. Co-morbidities seem to influence the response to (NT-pro)BNP-guided therapy and may explain the lower efficacy of this approach in elderly patients.
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Eur. J. Heart Fail. · Jul 2014
Review Meta AnalysisEffects of exercise training on depression in patients with heart failure: a systematic review and meta-analysis of randomized controlled trials.
The aim of this review is to assess the effects of exercise training on the symptoms of depression in heart failure (HF) patients. ⋯ Exercise training significantly decreased the symptoms of depression in patients with HF. This benefit remained unclear in cases of HF with a normal EF and combined aerobic and strength training. Random controlled trials are needed to verify the benefit of exercise in these populations, and in very old, asymptomatic, and severe HF patients.
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Eur. J. Heart Fail. · Mar 2013
Meta AnalysisEffects of Tai Chi training on exercise capacity and quality of life in patients with chronic heart failure: a meta-analysis.
Whether Tai Chi (TC) is effective in the cardiac rehabilitation of patients with chronic heart failure (CHF) remains controversial. We performed a meta-analysis to examine the effects of TC on exercise capacity and quality of life (QoL) in CHF patients. ⋯ TC may improve QoL in patients with CHF and could be considered for inclusion in cardiac rehabilitation programmes. However, there is currently a lack of evidence to support TC altering other important clinical outcomes. Further larger RCTs are urgently needed to investigate the effects of TC.
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Eur. J. Heart Fail. · Apr 2012
Review Meta AnalysisIron supplementation for the treatment of chronic heart failure and iron deficiency: systematic review and meta-analysis.
Over half of chronic heart failure (CHF) patients are anaemic, and iron deficiency is common. Iron replacement therapy (oral or i.v.) might improve exercise capacity and quality of life (QOL). ⋯ Intravenous iron therapy is associated with improved QOL parameters, reduction in hospitalizations, and increased 6MWD. Treatment with i.v. iron is safe, with no increased rate of adverse events. The results of our analysis are limited by the paucity of trials, and significant heterogeneity between trials.