Deutsche medizinische Wochenschrift
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Pheochromocytomas and paragangliomas (PPGL) can be related to a uniquely high rate of underlying germline and somatic mutations. Accordingly, they can be assigned into genetic clusters, which are related to a specific biochemical and clinical phenotype as well as a different long term prognosis. The present article discussed how emerging knowledge on the respective clusters allows individual patient management before, during and after occurrence of a PPGL to improve clinical outcome.
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Dtsch. Med. Wochenschr. · Nov 2021
[Intracoronary imaging - how plaque morphology impacts personal medical therapy].
Even with emerging evidence that the use of intracoronary imaging techniques can significantly support the interventional procedure, the use of intracoronary imaging during catheterization procedures still remains comparatively low. With the help of intracoronary imaging percutaneous coronary interventions can be optimized and fundamental information about the plaque morphology can be archived. This is not only beneficial in determining plaque vulnerability but can also assist in the interventional approach of complex lesions including calcified lesions, as well as lesions causing an acute coronary syndrome. Especially in the context of the latter, identification of the underlying entity may provide alternative personalized approaches for patients with acute coronary syndrome.
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Dtsch. Med. Wochenschr. · Nov 2021
[Clinical benefit of Tocilizumab and other immunomodulating agents for treatment of COVID-19].
The pathophysiological course of COVID-19 can be distinguished in a phase of viral replication and an inflammatory phase. Hyperinflammatory processes promote the development of severe COVID-19. Therefore, immunomodulating agents came into focus. ⋯ Treatment with JAK inhibitors is an option for hospitalized patients with moderate COVID-19. It should be emphasized that comedication of JAK inhibitors and Tocilizumab is not recommended. Further high quality research is required for the widespread use of immunomodulating agents in COVID-19.
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First goal in an emergency department must be the immediate recognition of patients at risk. The primary success of therapy depends mainly on whether a critical risk is identified immediately upon arrival at the central emergency department and appropriate therapy is initiated. In order to identify critical patients among the many patients with a wide range of diseases and, nurse-assisted initial assessment systems can help. The assessment thus represents a complex decision-making process to identify critically ill patients in times of high patient volume and limited resources.