Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete
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The appearance of myocardial infarctions in fertile women is to agree upon the concept of cardiovascular risk factors. Women without diabetes showed in 3 age groups up to 49 years 2.5-3.1 factors and with diabetes 4.4-4.8 factors, such as smoking, hyperlipoproteinaemia, hypertension, obesity, oral contraceptives, hyperuricaemia and diabetes mellitus, respectively. ⋯ A critical indication for oral contraceptives is recommended, if already one of the factors, such as smoking, hyperlipoproteinaemia, hypertension, obesity or diabetes mellitus is present, or, if possible, its removal before ordination. Also low-dose oral contraceptives must be regarded as a potential risk factor up to further clarification.
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The causal connection of aluminium accumulation in the organism and of toxic aluminium effects on the bone metabolism is at present regarded as extensively ascertained. On the other hand, there is no final consent about the fact which exact pathomechanisms are the basis of the aluminium effects. Apart from the direct interaction of aluminium with osseous transformation processes influences of the aluminium load of the body on significant, modulating the bone turnover extraosseous factors could be proved. Discussions about the complex pathogenetic principles of aluminium-induced bone changes concentrate themselves upon inhibitory effects of aluminium in the process of mineralisation, upon immediate toxicity of aluminium on the bone cells, potential interactions between aluminium and changed NSD-function as well as the influence of the aluminium accumulation on the vitamin-D-balance.