The journal of clinical hypertension
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J Clin Hypertens (Greenwich) · Apr 2016
Review Meta AnalysisAssociation of Thiazide-Type Diuretics With Glycemic Changes in Hypertensive Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.
Patients receiving thiazide diuretics have a higher risk of impaired glucose tolerance or even incident diabetes, but the change of blood glucose level varies across different trials. The aim of this study was to investigate the glycemic changes in hypertensive patients with thiazide-type diuretics. Twenty-six randomized trials involving 16,162 participants were included. ⋯ Patients receiving lower doses of thiazides (hydrochlorothiazide or chlorthalidone ≤25 mg daily) had less change in FPG (MD, 0.15 mmol/L [2.7 mg/dL]; 95% CI, 0.03-0.27) than those receiving higher doses (MD, 0.60 mmol/L [10.8 mg/dL]; 95% CI, 0.39-0.82), revealed by the subgroup analysis of thiazides vs calcium channel blockers. Thiazide-type diuretics are associated with significant but small adverse glycemic effects in hypertensive patients. Treatment with a lower dose might reduce or avoid glycemic changes.
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In the February 2014 issue of The Journal of Clinical Hypertension, the Editorial, “The World Hypertension League and International Society of Hypertension Call on Governments, Nongovernmental Organizations, and the Food Industry to Work to Reduce Dietary Sodium,” by Norm Campbell, MD, FRCPC; Daniel Lackland, DrPH, FACE, FAHA, FASH; Arun Chockalingam, MS, PhD, FACC; Liu Lisheng, MD; Ernesto L. Schiffrin, MD, PhD, FRSC, FRCPC, FACP; Stephen Harrap, MBBS, FRACP, PhD; Rhian M. ⋯ Aletta Schutte, PhD was incorrectly listed as Schutte Aletta, PhD. We apologize for the error.