Infusionstherapie und Transfusionsmedizin
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Infusionsther Transfusionsmed · Oct 1994
Randomized Controlled Trial Comparative Study Clinical TrialEffects of hypertonic saline hydroxyethyl starch solution on collagen-induced platelet aggregation and ATP secretion.
The purpose of this study was to investigate the effect of hypertonic (NaCl 7.5%) hydroxyethyl starch (HES 6%, molecular weight 200,000) (HHES) as used for small-volume resuscitation on global coagulation parameters and platelet function. ⋯ The changes in global coagulation parameters can be explained by dilutional effects of the infused solution. The hyperosmolar saline compound of the HHES solution obviously contributes to the slowing down of platelet aggregation. Osmotic stress and membrane pleating may aggravate HES-induced changes in membrane fluidity and microviscosity and thus explain this impaired interaction. The increase in ATP release suggests a change in receptor-second messenger interaction for delta granule release.