Farmakologiia i toksikologiia
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Comparative Study
[The thrombolytic activity of acylated activator complexes of plasmin-streptokinase with different rates of reactivation].
In the experiments on guinea-pigs with venous thrombosis there were studied the fibrin- and thrombolytic effects of streptokinase, the plasmin-streptokinase complex and the acylated derivatives of the complex with various rates of reactivation. It was established that the acylated derivatives of the plasmin-streptokinase complex possess greater stability in the blood flow and lead to more prolonged stimulation of fibrinolysis at less magnitude of its systemic activation. Due to this the acylated derivatives of the plasmin-streptokinase complex produce less pronounced fibrinogenolysis. In connection with a high affinity to fibrin their thrombolytic action does not depend on the systemic activation of fibrinolysis.
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Comparative Study
[A comparative study of the therapeutic and reactivating activities of alloxime and dipyroxime in acute poisoning of animals by organophosphate pesticides].
The therapeutic and reactivating activities of a new antidote alloxime were studied as compared with dipiroxime (TMB-4) during oral intoxication of animals by chlorophos and carbophos (LD50). When administered intramuscularly in a dose of 10 mg/kg, alloxime exhibited more pronounced therapeutic and reactivating effects (particularly in the central nervous system) as compared to dipiroxime.
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Comparative Study
[Pharmacology of various aminosteroidal muscle relaxants].
A large number of analogues of pancuronium and vecuronium have been tested for neuromuscular blocking and other actions in anaesthetized cats, dogs, pigs and monkeys in an attempt to find a nondepolarizing substitute for succinylcholine. The results demonstrated an inverse relationship between dose and brevity of action; that is to say that grief duration was found only among compounds of relatively low potency. Two compounds given the code numbers Org 7617 and Org 9616 were found to possess promising properties. ⋯ They do not release histamine or produce ganglion block, and they are both considerably less potent than pancuronium in blocking the cardiac vagus. Both may produce a small fall in blood pressure. Electrophysiological analysis shows that neither compound is expected to occlude the receptor-operated ion channels of the motor endplate in concentrations likely to be achieved clinically.
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Case Reports
[A spectrophotometric micromethod for the study of theophylline pharmacokinetics in children with bronchial asthma].
A spectrophotometric micromethod for determination of theophylline in the blood is proposed. Theophylline pharmacokinetics was studied by the method in 71 children with bronchial asthma. Doses and the number of administrations were selected individually for 45 patients under control of blood plasma theophylline concentration. Good clinical results were obtained.