Current psychiatry reports
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Curr Psychiatry Rep · Jun 2002
ReviewDelirium: an important (but often unrecognized) clinical syndrome.
Delirium is a clinical syndrome characterized by the acute onset of a disturbance in consciousness accompanied by a reduced ability to focus, sustain, or shift attention. It may foreshadow impending death in as many as 25% of hospitalized inpatients and may be a source of significant morbidity in those who present with this syndrome. ⋯ This paper will address this complex condition, focusing on its history, definition, epidemiology, pathophysiology, recognition, risk factors, and clinical quantification. Its prevention and treatment will be covered elsewhere in this journal.
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The mainstay of the pharmacologic management of delirium remains typical antipsychotics, primarily haloperidol. Typical antipsychotics are associated with significant side effects, particularly in the elderly. This article reviews the literature on the use of both typical and atypical antipsychotics in the management of acute delirium, with a focus on the elderly. ⋯ Anticholinergic toxicity is especially problematic in delirious, demented patients, because most dementias are associated with pre-existing deficiencies in cholinergic neurotransmission. These issues will be reviewed for typical antipsychotics as well as the emerging literature on the use of atypical antipsychotics-- risperidone, olanzapine, and quetiapine--for pharmacologic management of acute delirium. Data from two studies conducted at the Wesley Woods Center at Emory University will be briefly reviewed as they constitute the largest series to date investigating the pharmacologic management of delirious demented patients.