Current rheumatology reports
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Review
Effectiveness of transcutaneous electrical nerve stimulation for treatment of hyperalgesia and pain.
Transcutaneous electrical nerve stimulation (TENS) is a nonpharmacologic treatment for pain relief. TENS has been used to treat a variety of painful conditions. This review updates the basic and clinical science regarding the use of TENS that has been published in the past 3 years (ie, 2005-2008). ⋯ This review also highlights data from recent randomized, placebo-controlled trials and current systematic reviews. Clinical trials suggest that adequate dosing, particularly intensity, is critical to obtaining pain relief with TENS. Thus, evidence continues to emerge from both basic science and clinical trials supporting the use of TENS for the treatment of a variety of painful conditions while identifying strategies to increase TENS effectiveness.
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Various peripheral and spinal mechanisms have been hypothesized to contribute to pain amplification and chronicity. However, the role of the brain in chronic pain states remains to be fully elucidated. Functional brain imaging techniques, such as positron emission tomography and functional magnetic resonance imaging, have frequently been used to investigate brain activity during acute/experimental pain perception, which has helped to establish the notion of the human pain network. ⋯ It has been suggested that prolonged nociceptive input to the brain might induce functional and morphologic maladaptive processes that in turn further exacerbate the experience of chronic pain. Alternatively, morphologic changes might predispose toward vulnerability to develop a chronic pain state. The purpose of this review is to examine current literature regarding altered brain morphology in patients with various chronic pain states, summarize these findings, and evaluate their implications for our understanding of the pathophysiology of chronic pain.