Diabetes technology & therapeutics
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Diabetes Technol. Ther. · Apr 2014
Target attainment through algorithm design during intravenous insulin infusion.
Algorithms were designed under a single model, to attain differing designated glycemic targets during intravenous insulin infusion, and evaluated in order to justify computerization of the model. The approximate maintenance rate (MR) of insulin infusion is discovered according to rate of change of blood glucose (BG) and previous insulin infusion rate (IR). During treatment, re-assignment of IR depends on MR and BG. For each MR, a roughly sigmoidal relationship between BG and IR is specified, such that the inflection point falls approximately at a true target BG. ⋯ The pilot series suggests that once target range BG is attained, maintenance of control within each of three distinct BG target ranges is achievable, according to choice of algorithm.