Medical and pediatric oncology
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Med. Pediatr. Oncol. · Jun 2001
Comparative StudyPharmacokinetic longitudinal studies of antibiotics administered via a permanent intraosseous device in micropigs.
In critically ill children, intraosseous (IO) administration of a medicine provides an alternate vascular access route when IV access is not readily available. We investigated the short and long-term efficacy and safety of a totally intraosseously implantable device. ⋯ Long-term administration of antibiotics through a totally implantable intraosseous device is feasible and safe in micropigs. Although the procedure seems promising, additional studies of the continuous infusion of chemotherapeutic agents, blood products and antimicrobial solutions are needed prior to use in humans.