Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
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Amyotroph. Lateral Scler. Other Motor Neuron Disord. · Sep 2000
Expression of nitric oxide synthase isoforms in spinal cord in amyotrophic lateral sclerosis.
Autoradiography with [3H]nitro-L-arginine (3HL-NNA) was used to quantify nitric oxide synthase (NOS), and immunocytochemistry to identify NOS isoforms, in spinal cord in amyotrophic lateral sclerosis (ALS) and controls. ⋯ Expression of abnormal variants of nNOS or increased expression of iNOS may have a role in motoneuron death in ALS.