Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
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Amyotroph. Lateral Scler. Other Motor Neuron Disord. · Mar 2002
ReviewAmyotrophic lateral sclerosis: evaluation and treatment of respiratory impairment.
Patients with amyotrophic lateral sclerosis (ALS) invariably develop respiratory muscle weakness and most die from pulmonary complications. There are numerous tests available to evaluate respiratory status in ALS and it is important to understand their various advantages and limitations. Forced vital capacity (FVC) is commonly used but can remain normal despite substantial inspiratory muscle weakness. ⋯ Observational studies have demonstrated improved survival and quality of life with noninvasive ventilation. Tracheostomy with long-term mechanical ventilation is not frequently used but can be an important component of care for ALS. This review describes an approach to respiratory evaluation and care of patients with ALS.
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Amyotroph. Lateral Scler. Other Motor Neuron Disord. · Mar 2002
Clinical Trial Controlled Clinical TrialNo effect of creatine on respiratory distress in amyotrophic lateral sclerosis.
To evaluate the effect of creatine supplementation on the respiratory function of patients with advanced amyotrophic lateral sclerosis (ALS). ⋯ The present study did not show any clinically significant, long-term effect of creatine on the function of respiratory muscles in ALS patients with respiratory distress.