Journal of the autonomic nervous system
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J. Auton. Nerv. Syst. · Aug 1987
Comparative StudyOxytocin administered intrathecally preferentially increases heart rate rather than arterial pressure in the rat.
Oxytocin was administered intrathecally at a dose of 6.5 nmol to the 9th or 2nd thoracic level of the spinal cord in the rat. This increased heart rate but had no effect on arterial pressure. The increase in heart rate began within 1 and 5 min and reached a peak at 10-30 min; the maximum increase, at 10 min after administration, at the second thoracic level was 65.4 +/- 13.8 (S. ⋯ It is concluded that the intrathecal administration of reached a maximum of 0.6% of the total injected by 30 min after administration. It is concluded that the intrathecal administration of oxytocin increases heart rate via an action in the spinal cord, presumably on sympathetic preganglionic neurons. Our results are consistent with earlier suggestions that oxytocin may be a chemical mediator of synaptic transmission onto sympathetic preganglionic neurons.