Osaka city medical journal
-
Phosphodiesterase type III inhibitors are often delivered by continuous intravenous infusion without initial loading to prevent hypotension, i.e., by "slow induction". We evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of olprinone slow induction after open-heart surgery. ⋯ Olprinone slow induction is useful and safe for critically ill patients.