Mathematical biosciences
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Mathematical biosciences · Jun 2011
Comparative StudyThe role of optimal control in assessing the most cost-effective implementation of a vaccination programme: HPV as a case study.
Vaccination against the human papillomavirus (HPV) is a recent development in the UK. This paper uses an optimal control model to explore how best to target vaccination. ⋯ Extending the model to include male vaccination, we find that including males in a vaccination strategy is cost-effective. We compare the optimal control solution to that from a constant control model and show that the optimal control model is more efficient at forcing the system to a disease-controlled steady state.