Mathematical biosciences
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Mathematical biosciences · Feb 2014
Estimation of kinetic parameters in an S-system equation model for a metabolic reaction system using the Newton-Raphson method.
Metabolic reaction systems can be modeled easily in terms of S-system type equations if their metabolic maps are available. This study therefore proposes a method for estimating parameters in decoupled S-system equations on the basis of the Newton-Raphson method and elucidates the performance of this estimation method. ⋯ The method is also applied to time course data with noise and found to estimate parameters efficiently. Results indicate that the present method has the potential to be extended to a method for estimating parameters in large-scale metabolic reaction systems.