Journal of acquired immune deficiency syndromes : JAIDS
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J. Acquir. Immune Defic. Syndr. · Aug 2007
Randomized Controlled Trial Clinical TrialDronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep.
Individuals with HIV constitute the largest group using cannabinoids for medicinal reasons; yet, no studies have directly compared the tolerability and efficacy of smoked marijuana and oral dronabinol maintenance in HIV-positive marijuana smokers. This placebo-controlled within-subjects study evaluated marijuana and dronabinol across a range of behaviors: eating topography, mood, cognitive performance, physiologic measures, and sleep. ⋯ These data suggest that for HIV-positive marijuana smokers, both dronabinol (at doses 8 times current recommendations) and marijuana were well tolerated and produced substantial and comparable increases in food intake.
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J. Acquir. Immune Defic. Syndr. · Aug 2007
Transient viremia, plasma viral load, and reservoir replenishment in HIV-infected patients on antiretroviral therapy.
When antiretroviral therapy (ART) is administered for long periods to HIV-1-infected patients, most achieve viral loads that are "undetectable" by standard assay methods (ie, HIV-1 RNA <50 copies/mL). Despite sustaining viral loads lower than the level of detection, a number of patients experience unexplained episodes of transient viremia or viral "blips." We propose that transient activation of the immune system by infectious agents may explain these episodes of viremia. ⋯ This effect can be more profound than is predicted by simply lowering the baseline viral load from which blips originate. Finally, we suggest that sporadic immune activation may elevate the level of chronically infected cells and replenish viral reservoirs, including the latent cell reservoir, providing a mechanism for recurrent viral blips and low levels of viremia under ART.
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J. Acquir. Immune Defic. Syndr. · Aug 2007
Declining HIV infection rates among recently married primigravid women in Pune, India.
A single recent study has suggested a decrease in HIV risk for women attending antenatal clinics (ANCs) in southern India. Yet, some have questioned the validity of the Indian national surveillance data and analyses. Previous studies suggest that the only major HIV risk factor for married Indian women is the risk behavior of their husbands. Therefore, to address concerns about potential selection bias in the analysis of sentinel surveillance data from multiple sites, we estimated the trajectory of HIV transmission rates among recently married, monogamous, primigravid women attending a single large ANC in Pune, India. ⋯ HIV infection risk among young primigravid women in Pune seems to have decreased over the past 3.5 years. A decreasing HIV risk among pregnant women in Pune would also decrease the number of HIV-exposed infants. We hypothesize that decreased high-risk sexual behavior among young recently married men is most likely contributing to a decreasing risk to their wives and children in Pune.
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J. Acquir. Immune Defic. Syndr. · Aug 2007
Condom use rather than serosorting explains differences in HIV incidence among men who have sex with men.
HIV incidence is high and increasing among men who have sex with men (MSM) attending the Sexually Transmitted Infection (STI) Outpatient Clinic in Amsterdam but remains low among MSM in the Amsterdam Cohort Studies (ACS). We studied whether sexual behaviors in these 2 groups are consistent with serosorting and if serosorting explains the difference in HIV incidence. ⋯ Sexual risk behaviors with traceable partners are consistent with serosorting. Nonetheless, the higher level of UAI with anonymous or nonconcordant traceable partners more likely explains the increasing HIV incidence seen among STI Outpatient Clinic attendees than a difference in serosorting behavior.
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J. Acquir. Immune Defic. Syndr. · Aug 2007
Comparison of clinical response to initial highly active antiretroviral therapy in the patients in clinical care in the United States and Brazil.
US and Brazilian studies indicate that highly active antiretroviral therapy (HAART) has been effective in reducing morbidity and mortality from HIV/AIDS. Differences exist in the adoption and patterns of antiretroviral drug use and in the incidence of AIDS-defining illness (ADI) between the 2 countries, however, and there has not been a direct comparison of clinical response between Brazil and the United States. We sought to determine if there have been differences in the clinical response to HAART from HIV clinical practices in the United States and Brazil. ⋯ There were only minor differences in clinical response to the use of HAART comparing Rio de Janeiro with Baltimore, despite differences in patterns of antiretroviral drug use and ADI incidence. This analysis indicates that HAART can be similarly effective in treating HIV/AIDS in countries with different economies.