Neurorehabilitation and neural repair
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Neurorehabil Neural Repair · Dec 2002
Comparative Study Clinical TrialMotor recovery and cortical reorganization after constraint-induced movement therapy in stroke patients: a preliminary study.
Constraint-induced movement therapy (CIMT) is a physical rehabilitation regime that has been previously shown to improve motor function in chronic hemiparetic stroke patients. However, the neural mechanisms supporting rehabilitation-induced motor recovery are poorly understood. The goal of this study was to assess motor cortical reorganization after CIMT using functional magnetic resonance imaging (fMRI). ⋯ The behavioral effects of CIMT were associated with a trend toward a reduced LI from pre-intervention to immediately post-intervention (LI = -0.01+/-0.06, P = 0.077) and 6 months post-intervention (LI = -0.03+/-0.15). Stroke-affected hand movement was not accompanied by mirror movements during fMRI, and electromyographic measures of mirror recruitment under simulated fMRI conditions were not correlated with LI values. These data provide preliminary evidence that gains in motor function produced by CIMT in chronic stroke patients may be associated with a shift in laterality of motor cortical activation toward the undamaged hemisphere.
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Neurorehabil Neural Repair · Dec 2002
Rehabilitation Practice through Science and Research. Abstracts of the 79th annual meeting of the American Congress of Rehabilitation Medicine and the 9th annual meeting of the American Society of Neurorehabilitation. October 3-6, 2002. Philadelphia, Pennsylvania, USA.