Neurorehabilitation and neural repair
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Neurorehabil Neural Repair · May 2012
Neural correlates of the antinociceptive effects of repetitive transcranial magnetic stimulation on central pain after stroke.
Repetitive transcranial magnetic stimulation (rTMS) modulates central neuropathic pain in some patients after stroke, but the mechanisms of action are uncertain. ⋯ . Mood may affect the modest antinociceptive effects of rTMS that we found, which may be mediated by the superior TCT through modulation of a distributed pain network.
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Neurorehabil Neural Repair · May 2012
Promotion of recovery from thoracic spinal cord contusion in rats by stimulation of medullary raphe or its midbrain input.
. Brainstem regions with descending axons could influence recovery after spinal cord injury, thus presenting potential targets for treatment. Neurons in the hindbrain raphe magnus respond to sensory and chemical concomitants of trauma (eg, pain, circulating cytokines) and release trophic substances (serotonin, neuropeptides) in widespread spinal regions. ⋯ . Raphe magnus neurons mediate restorative feedback in acute spinal cord injury. Their interim activation, direct or indirect (via periaqueductal gray), offers a basis for possible treatments in patients.